chemical biology

Diversity-Oriented Synthesis Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology【電子書籍】 Andrea TrabocchiNucleic Acids in Medicinal Chemistry and Chemical Biology Drug Development and Clinical Applications【電子書籍】Inorganic Chemical Biology Principles, Techniques and Applications【電子書籍】 Gilles Gasser【中古】【未使用 未開封品】Idiotypes in Biology and Medicine (Chemical Immunology)Protein Homeostasis in Drug Discovery A Chemical Biology Perspective【電子書籍】Ion Channels: Channel Chemical Biology, Engineering, and Physiological Function【電子書籍】 Daniel L. MinorHydrogen Sulfide Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies【電子書籍】 Binghe WangThe Chemical Biology of Nitrogen【電子書籍】 Christopher T WalshChemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C【電子書籍】 Arun K. ShuklaDNA Repair Enzymes: Cell, Molecular, and Chemical Biology【電子書籍】 Brandt EichmanHomocysteine in Protein Structure/Function and Human Disease Chemical Biology of Homocysteine-containing Proteins【電子書籍】 Hieronim Jakubowski洋書 Paperback, Chemical and Synthetic Approaches in Membrane Biology (Springer Protocols Handbooks)Mass Spectrometry in Chemical Biology: Evolving Applications MASS SPECTROMETRY IN CHEMICAL (Chemical Biology) Norberto Peporine LopesNovel Chemical Tools to Study Ion Channel Biology【電子書籍】Glycoscience: Chemistry and Chemical Biology GLYCOSCIENCE REV/E 2/E 3V Gregory L. CoteProtein Degradation with New Chemical Modalities Successful Strategies in Drug Discovery and Chemical Biology【電子書籍】Computational Tools for Chemical Biology COMPUTATIONAL TOOLS FOR CHEMIC ーProtein Crystallography: Challenges and Practical Solutions PROTEIN CRYSTALLOGRAPHY (Chemical Biology) Konstantinos BeisAdvanced Chemical Biology Chemical Dissection and Reprogramming of Biological Systems【電子書籍】Inducing Targeted Protein Degradation From Chemical Biology to Drug Discovery and Clinical Applications【電子書籍】
 

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  • <p><strong>Discover an enhanced synthetic approach to developing and screening chemical compound libraries</strong></p> <p>Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology.</p> <p><em>Diversity-Oriented Synthesis</em> begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four par...
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  • <p>Nucleic Acids in Medicinal Chemistry and Chemical Biology</p> <p><strong>An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications</strong></p> <p>In <em>Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications</em>, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers.</p> <p>The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the rea...
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  • <p>Understanding, identifying and influencing the biological systems are the primary objectives of<br /> chemical biology. From this perspective, metal complexes have always been of great assistance<br /> to chemical biologists, for example, in structural identification and purification of essential<br /> biomolecules, for visualizing cellular organelles or to inhibit specific enzymes. This inorganic side<br /> of chemical biology, which continues to receive considerable attention, is referred to as inorganic<br /> chemical biology.</p> <p><em>Inorganic Chemical Biology: Principles, Techniques and Applications</em> provides a comprehensive<br /> overview of the current and emerging role of metal complexes in chemical biology. Throughout all<br /> of the chapters there is a strong emphasis on fundamental theoretical chemistry and experiments<br /> that have been carried out in living cells or organisms. Outlooks for the future applications of<br /> metal c...
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  • 【中古】【未使用・未開封品】Idiotypes in Biology and Medicine (Chemical Immunology)【メーカー名】【メーカー型番】【ブランド名】【商品説明】Idiotypes in Biology and Medicine (Chemical Immunology)【注意】こちらは輸入品となります。当店では初期不良に限り、商品到着から7日間は返品を 受付けております。こちらは当店海外ショップで一般の方から買取した未使用・未開封品です。買取した為、中古扱いとしております。他モールとの併売品の為、完売の際はご連絡致しますのでご了承ください。ご注文からお届けまで1、ご注文⇒ご注文は24時間受け付けております。2、注文確認⇒ご注文後、当店から注文確認メールを送信します。3、当店海外倉庫から当店日本倉庫を経由しお届けしますので10〜30営業日程度でのお届けとなります。4、入金確認⇒前払い決済をご選択の場合、ご入金確認後、配送手配を致します。5、出荷⇒配送準備が整い次第、出荷致します。配送業者、追跡番号等の詳細をメール送信致します。6、到着⇒出荷後、1〜3日後に商品が到着します。 ※離島、北海道、九州、沖縄は遅れる場合がございます。予めご了承下さい。お電話でのお問合せは少人数で運営の為...
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  • <p><strong>Protein Homeostasis in Drug Discovery</strong></p> <p><strong>Comprehensive resource on all aspects of protein homeostasis, covering both historical perspectives and emerging technologies that are revolutionizing the field</strong></p> <p><em>Protein Homeostasis in Drug Discovery</em> highlights drug discovery and development efforts targeting protein homeostasis and considers the emerging appreciation that a protein’s activity may not be the only factor to consider when developing therapeutic agents.</p> <p>The chapters cover various aspects of protein homeostasis such as cellular localization, abundance, interactions, and more. Moreover, the text contains up-to-date information regarding targeted protein degradation, an emerging drug discovery modality.</p> <p>Readers interested in targeting different regulatory events that control protein homeostasis or modulating protein abundance will find this book an excellent resource. Furthermore, th...
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  • <p><em>Ion Channels, Part C, Volume 653 in the Methods in Enzymology series,</em> highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including Nonsense suppression in ion channels, Engineering Ion Channels Using Protein Trans-splicing, Probing Ion Channel Neighborhoods Using APEX, STX based probes for NaVs, ANAP: a versatile, fluorescent probe of ion channel gating and regulation, High Throughput Screens for Small Molecule Ion Channel Modulators, Using toxins to study ion channels, Re/de-constructing ubiquitin regulation of ion channels, Tethered Peptide Toxins for Ion Channels, Voltage-Sensing Phosphatase Molecular Engineering, and more.</p> <p>Additional chapters cover Engineering excitable cells, Stretch and Poke Stimulation of Mechanically-Activated Ion Channels, Optical Control of STIM Channels, High Throughput Electrophysiological Evaluation of Mutant Ion Channels, Evaluating BEST1 Mutations in RPE Stem C...
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  • <p><strong>HYDROGEN SULFIDE</strong></p> <p><strong>Covers H2S interactions, methods of detection and delivery in biological environments, and a wide range of applications</strong></p> <p>Research on hydrogen sulfide (H2S) spans diverse disciplines including chemistry, biology, and physiology. In recent years, new materials and approaches have been developed to deliver H2S and related reactive sulfur species in various clinical contexts. Although many biological pathways involving H2S are complex, all are governed by fundamental chemical interactions between reactive sulfur species and other molecular entities.</p> <p><em>Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies</em> provides the foundation required for understanding the fundamental chemical biology of H2S while highlighting the compound’s therapeutic potential and medicinal applications. This book covers key aspects of H2S chemical biology, in...
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  • <p>From DNA and RNA to proteins and vitamins the role of nitrogen is central in organismal metabolism. <em>The Chemical Biology of Nitrogen</em> comprehensively examines how the chemistry available to both inorganic and organic nitrogen compounds both enable and conditions the vast array of nitrogen biologies. This book provides a chemocentric approach to both the inorganic and organic chemical biology of nitrogen. Following an introduction to nitrogen trivalency the book progresses through the logic of inorganic nitrogen metabolism and organic nitrogen metabolites to nitrogen proteomics with an integrative approach to understanding the role of nitrogen in its many biologic roles. Authored by a renowned scientist and educator, this book is ideal for researchers in chemical biology and nitrogen metabolism and will be of particular interest to advanced students and postgraduates in biochemistry and chemical biology.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は...
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  • <p><em>Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C, Volume 633</em>*,* the latest release in the <em>Methods in Enzymology</em> series,continues the legacy of this premier serial. This release includes sections on Next generation probes for molecular imaging in cells, Competitive binding assay for biotin and biotin derivatives, based on avidin and biotin-4-fluorescein, Converting avidin to bind ligands other than biotin, especially steroids, Chemoenzymatic Labeling Strategy, Engineered Siderophores, Small molecules to inhibit bacterial population behavior, NMR tube bioreactor, Small molecule controlled RAS activation system, Small molecule regulated Cas9, the Design and application of synthetic receptors, and much more.</p> <ul> <li>Contains the authority of authors who are leaders in their field</li> <li>Provides a comprehensive source on new methods and research in enzymology</li> </ul>画面が切り替わりますので、しばら...
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  • <p><em>DNA Repair Enzymes, Part A, Volume 591</em> is the latest volume in the <em>Methods in Enzymology</em> series and the first part of a thematic that focuses on DNA repair enzymes. Topics in this new release include chapters on the Optimization of Native and Formaldehyde iPOND Techniques for Use in Suspension Cells, the Proteomic Analyses of the Eukaryotic Replication Machinery, DNA Fiber Analysis: Mind the Gap!, Comet-FISH for Ultrasensitive Strand-Specific Detection of DNA Damage in Single Cells, Examining DNA Double-Strand Break Repair in a Cell Cycle-Dependent Manner, Base Excision Repair Variants in Cancer, and Fluorescence-Based Reporters for Detection of Mutagenesis in E. coli.</p> <ul> <li>Includes contributions from leading authorities working in enzymology</li> <li>Focuses on DNA repair enzymes</li> <li>Informs and updates on all the latest developments in the field of enzymology</li> </ul>画面が切り替わりますので、しばらくお待ち下さい。 ※...
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  • <p>Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broa...
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  • *** We ship internationally, so do not use a package forwarding service. We cannot ship to a package forwarding company address because of the Japanese customs regulation. If it is shipped and customs office does not let the package go, we do not make a refund. 【注意事項】 *** 特に注意してください。 *** ・個人ではない法人・団体名義での購入はできません。この場合税関で滅却されてもお客様負担になりますので御了承願います。 ・お名前にカタカナが入っている場合法人である可能性が高いため当店システムから自動保留します。カタカナで記載が必要な場合はカタカナ変わりローマ字で記載してください。 ・お名前またはご住所が法人・団体名義(XX株式会社等)、商店名などを含めている場合、または電話番号が個人のものではない場合、税関から法人名義でみなされますのでご注意ください。 ・転送サービス会社への発送もできません。この場合税関で滅却されてもお客様負担になりますので御了承願います。 *** ・注文後品切れや価格変動でキャンセルされる場合がございますので予めご了承願います。 ・当店でご購入された商品は、原則として、「個...
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  • MASS SPECTROMETRY IN CHEMICAL Chemical Biology Norberto Peporine Lopes Ricardo Roberto Da Silva ROYAL SOCIETY OF CHEMISTRY2017 Hardcover English ISBN:9781782625278 洋書 Computers & Science(コンピューター&科学) Science
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  • <p>This volume describes chemical approaches to assess ion channel structure, function and pharmacology. Topics discussed include the use of engineered ionizable side chains to obtain information on permeation pathways and the local environment; the modification of engineered cysteine side chains, including cysteine scanning mutagenesis and the attachment of fluorescent probes and bio-reactive tethers; and the nascent use of genetic code expansion, evaluating its applications to ion channel and membrane proteins. This comprehensive text provides multifaceted perspectives on the great diversity of state-of-the-art methods which take advantage of the ever-expanding chemical toolbox to study ion channel biology.</p> <p>Capturing the contributions and innovations of renowned laboratory researchers in transmembrane protein study for the first time, this book is comprehensive in scope. It covers a wide array of experimental approaches: photochemistry, novel biological tools, and inn...
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  • GLYCOSCIENCE REV/E 2/E 3V Gregory L. Cote Bertram O. FraserーReid Kuniaki Tatsuta SPRINGER NATURE2008 Hardcover Revised English ISBN:9783540361541 洋書 Computers & Science(コンピューター&科学) Science
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  • <p>Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally ‘difficult to target’ proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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  • COMPUTATIONAL TOOLS FOR CHEMIC ー ROYAL SOCIETY OF CHEMISTRY2017 Hardcover English ISBN:9781782627005 洋書 Computers & Science(コンピューター&科学) Science
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  • PROTEIN CRYSTALLOGRAPHY Chemical Biology Konstantinos Beis Gwyndaf Evans ROYAL SOCIETY OF CHEMISTRY2018 Hardcover English ISBN:9781782627289 洋書 Computers & Science(コンピューター&科学) Science
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  • <p><strong>Advanced Chemical Biology</strong></p> <p><strong>The modern approach to teaching chemical biology</strong></p> <p><em>Advanced Chemical Biology</em> is organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures, including core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis. Advanced topics and applications in, e. g., microbiology, developmental biology, and neurobiology, are covered in separate sections.</p> <p>Every chapter is homogeneous in style and layout, consisting of a short historical introduction followed by a description of the underlying concepts and a selection of recent examples of how the concept has been turned into practice. The subdivision of the contents into core and supplemental chapters enables a flexible use in teaching, both for a one-semester and a two-semester course.</p> <p...
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  • <p><strong>Inducing Targeted Protein Degradation</strong></p> <p><strong>Enables drug developers in academia and industry to expand the range of accessible drug targets through induced protein degradation</strong></p> <p>Since the breakthrough of the PROTAC technology in 2015, targeted protein degradation has revolutionized drug discovery, enabling pharma companies to develop completely novel therapeutics. <em>Inducing Targeted Protein Degradation</em> is a timely guide to navigating the complexities of the subject and understanding its practical application, with an eye on expanding the druggable space.</p> <p>In <em>Inducing Targeted Protein Degradation</em>, readers will find the most recent information on:</p> <ul> <li>Cellular mechanisms of targeted protein degradation and current approaches to utilize these mechanisms for drug discovery</li> <li>A comparison of different induced degradation approaches, including PROTAC, molecular glues, ...
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